Catalog # Availability Size / Price Qty
Ribociclib | CAS No. 1211441-98-3 | Cyclin-dependent Kinase Inhibitors
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Description: Dual cdk4/cdk6 inhibitor; orally bioavailable
Alternative Names: LEE-011

Chemical Name: 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Product Details

Biological Activity

Dual cdk4/cdk6 inhibitor. Induces G1 phase cell cycle arrest and senescence in neuroblastoma cell lines (IC50 = 306 nM). Delays tumor growth in vivo. Orally bioavailable.

Technical Data

Soluble to 10 mM in DMSO
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma.
    Rader et al.
    Clin. Cancer Res., 2013;19:6173

Product Datasheets

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