Dkk-4 Proteins and Enzymes

Dickkopf related protein 4 (Dkk-4) is a member of the Dkk protein family of secreted Wnt antagonists. Dkk-1 and Dkk-4 antagonize Wnt/beta-catenin signaling by direct high affinity binding to the Wnt coreceptor LRP5/6 and inhibiting interaction of LRP5/6 with the Wnt-Frizzled complex. Dkk-1 and Dkk-4 also bind the transmembrane proteins Kremen-1 and...