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2 results for "GLP-1R" in Products
GLP-1R Products
GLP-1 R (Glucagon-like Peptide 1 Receptor) is a class B, G protein-linked, seven transmembrane domain protein that is expressed in pancreas, lung, heart, kidney, hypothalamus, and stomach. It is a receptor for Glucagon-like Peptide, a regulator of insulin secretion by pancreatic beta cells. Drugs that target GLP-1 R are of great interest for diabetes related research. Known agonists for GLP-1 R include GLP-1, Boc5, and Cpd1. Following experiments in mouse models, GLP-1 R agonists may also useful in the treatment of acute myocardial infarction.
Positive allosteric modulator of GLP-1 receptors
| Chemical Name: | 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine |
| Purity: | ≥98% |
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Negative allosteric modulator of glucagon and GLP-1 receptors
| Chemical Name: | 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide |
| Purity: | ≥98% |
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