NNC 0640

Key Product Details

Product Description

NNC 0640 is a negative allosteric modulator of glucagon receptors (pK_i = 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulation in vitro.

Product Specifications for NNC 0640

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NNC 0640

The following data is based on the product molecular weight 573.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.74 mL	8.72 mL	17.43 mL
5 mM	0.35 mL	1.74 mL	3.49 mL
10 mM	0.17 mL	0.87 mL	1.74 mL
50 mM	0.03 mL	0.17 mL	0.35 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jazayeri Extra-helical binding site of a glucagon receptor antagonist. Nature. 2016 PMID: 27111510
• Song Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 PMID: 28514449
• Zhang Structure of the full-length glucagon class B g-protein-coupled receptor. Nature. 2017 PMID: 28514451

Product Documents for NNC 0640