Chemical Name: 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide
Biological ActivityNegative allosteric modulator of glucagon receptors (pKi = 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulation in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure of the full-length glucagon class B g-protein-coupled receptor.
Zhang et al.
Extra-helical binding site of a glucagon receptor antagonist.
Jazayeri et al.
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Song et al.
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