Chemical Name: 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide
Biological ActivityNNC 0640 is a negative allosteric modulator of glucagon receptors (pKi = 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulation in vitro.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure of the full-length glucagon class B g-protein-coupled receptor.
Zhang et al.
Extra-helical binding site of a glucagon receptor antagonist.
Jazayeri et al.
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Song et al.
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