Chemical Name: 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine
Biological ActivityBETP is a selective positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. Increases binding affinity of oxyntomodulin for the GLP-1 receptor. Potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Has no effect on GLP-2, GIP, PTH or glucagon receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the Insotropic effect of oxyntomodulin.
Willard et al.
Novel small molecule glucagon-like peptide-1 receptor agonist stimulates Ins secretion in rodents and from human islets.
Sloop et al.
Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently.
Cheong et al.
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