IGFLR1: Products

IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA.

IGF-II R is a type I transmembrane glycoprotein that contains a 2,264 amino acid (aa) extracellular region, a 23 aa transmembrane segment segment and a 124 aa cytoplasmic tail. IGF-II R regulates many diverse biological functions that range from intracellular trafficking to the internalization of extracellular factors and modulation of cellular responses. It delivers newly synthesized M6P-tagged lysosomal enzymes from the trans-golgi network to endosomes, and facilitates the clearance of extracellular lysosomal and matrix degrading enzymes by internalization into clathrin-coated vesicles and delivery into endosomes. With respect to IGF-II biology, It would appear that IGF-II R is principally a regulator of local IGF-II levels, targeting IGF-II for destruction in lysosomes.

The heterotetrameric receptors for insulin (INS R) and IGF-I (IGF-I R) are receptor tyrosine kinases that consist of two ligandbinding alpha subunits and two beta subunits. Ligand binding induces autophosphorylation on multiple tyrosine residues of beta subunits. Phosphorylation of Tyr1162 and 1163 on INS R and Tyr1135 and 1136 on IGF-I R stimulates intrinsic kinase activity.

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Human IGFLR1 Antibody

1 Image
B/N, CyTOF-ready, Flow

Human IGFLR1 (Teprotumumab) Biotinylated Antibody

Recombinant Monoclonal Antibody

Human IGFLR1 (Teprotumumab) Antibody

Recombinant Monoclonal Antibody.

Human IGFLR1 (Teprotumumab) Alexa Fluor® 488-conjugated Antibody

Recombinant Monoclonal Antibody.

Human IGFLR1 (Teprotumumab) Alexa Fluor® 647-conjugated Antibody

Recombinant Monoclonal Antibody.

Recombinant Human IGFLR1 Protein, CF

Bioactivity

Human IGFLR1 (Teprotumumab) Alexa Fluor® 700-conjugated Antibody

Recombinant Monoclonal Antibody.
Flow

Human IGFLR1 (Teprotumumab) Alexa Fluor® 750-conjugated Antibody

Recombinant Monoclonal Antibody.
Flow

Human IGFLR1 (Teprotumumab) Alexa Fluor® 594-conjugated Antibody

Recombinant Monoclonal Antibody.
Flow

Human IGFLR1 (Teprotumumab) Alexa Fluor® 350-conjugated Antibody

Recombinant Monoclonal Antibody.
Flow

Human IGFLR1 (Teprotumumab) Alexa Fluor® 405-conjugated Antibody

Recombinant Monoclonal Antibody.
Flow
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