Human IGFLR1 PE-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB8296P-025

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Detection of IGFLR1 in Human Blood Lymphocytes by Flow Cytometry.
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Human IGFLR1 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human IGFLR1 in direct ELISAs.
Source
Monoclonal Mouse IgG1 Clone # 905338
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human embryonic kidney cell line HEK293-derived recombinant human IGFLR1
Met1-Pro163
Accession # Q9H665
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of IGFLR1 antibody in Human Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of IGFLR1 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD3e APC-conjugated Monoclonal Antibody (Catalog # FAB100A) and either (A) Mouse Anti-Human IGFLR1 PE-conjugated Monoclonal Antibody (Catalog # FAB8296P) or (B) Mouse IgG1Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: IGFLR1

Insulin Growth Factor-like Family Receptor 1 (IGFLR1) is a 355 amino acid (aa) type 1a transmembrane protein that was identified in a screen for binding partners of human IGFL1 (1). Mature human IGFLR1 consists of an extracellular domain (ECD) with two putative cysteine-rich domains (CRDs), a transmembrane region, and a cytoplasmic domain (1). Its structure has similarities to TNF receptor family members (1). Over the first 163 aa, human IGFLR1 shares 61% and 59% aa sequence identity with mouse and rat IGFLR1, respectively. In mice, IGFLR1 is expressed primarily on T cells and, similar to the human proteins, mouse IGFLR1 binds the mouse IGFL protein (1). Human IGFL1 expression is enhanced by TNF-alpha treatment and was shown to be up-regulated in human psoriatic skin samples, suggesting that IGFLR1 may have a role during skin inflammation (1).

References
  1. Lobito, A.A. et al. (2011) J. Biol. Chem. 286:18969.
Long Name
IGF-like Family Receptor 1
Entrez Gene IDs
79713 (Human); 101883 (Mouse); 499126 (Rat)
Alternate Names
FLJ22573; IGFLR1; TMEM149; transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 4; U2AF1L4

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