Lgr4/GPR48 Products

Lgr4, also called GPR48, is a 7TM receptor that forms complexes with R-Spondins, Frizzled Wnt receptors and LRP Wnt co-receptors. It enhances Wnt-dependent LRP phosphorylation, internalization of LRPs, and accumulation of beta-catenin. Rodent Lgr4 is widely expressed in both embryo and adult. Lgr4 deletion inhibits fetal liver definitive erythropoi...