Volume 2, Issue 4, Summer 2026
You CAN significantly increase the speed and throughput of charge and size analysis using Maurice systems! This article discusses the advantages of implementing the SupersonicIEF and FlexsonicIEF methods to reduce run times for charge variant analysis; in addition, with the newer icIEF 400 and the Turbo CE-SDS cartridges you can increase the number of injections, batch sizes and runs for faster, comprehensive, high-quality analysis of biotherapeutic antibodies through charge (icIEF) and size (CE-SDS) analysis.
Industry News
- Mergers: Merck KGaA, Darmstadt, Germany, Agrees to Acquire Bio-Techne, Strengthening Leadership Position in Fast-Growing Life Sciences Markets Read full Press Release
- There's a new and upcoming center for personalized genetic therapies. Read full story.
- UK houses the Phase I clinical trial for the first Ebola virus vaccine. Read more.
- China creates and approves the world's first CAR-T therapy for solid tumors. Read full story.
Maurice and MauriceFlex Instruments and consumables are now part of the R&D Systems Family! The R&D Systems portfolio brings together Bio-Techne's trusted proteins, antibodies, immunoassays, small molecules, and innovative instruments used by scientists worldwide. This change is designed to help you navigate our portfolio faster and with greater clarity.
This integration allows you to access all your Maurice products, resources, and software updates directly on the R&D Systems website. Whether you're exploring instrumentation, seeking technical support, or downloading the latest software updates, you'll find everything conveniently consolidated to streamline your research experience.
Meet the Maurice Family
This recently updated brochure highlights the latest data and applications for your one-stop solution for automated icIEF and CE-SDS across all process stages. The MauriceFlex instrument features an additional icIEF-fractionation capability for further characterization of charge variants. Discover how to improve resolution, save time, and reduce hazardous waste compared to IEX and SDS-PAGE methods.
Publication: Development of the SupersonicIEF Method for High-Throughput Charge Variant Analysis
This peer reviewed article describes the SupersonicIEF method, which enables higher throughput charge variant analysis using icIEF method – up to two to three times faster than standard methods, allowing more rapid analysis of biotherapeutics to facilitate greater understanding and better optimization for production and formulation.
Guide: Accelerating icIEF and Fractionation Workflows
This Guide to Assay Optimization for Maurice and MauriceFlex Systems describes the SupersonicIEF method that reduces the time to obtain charge heterogeneity results from 15 to 5 minutes. In addition, the FlexsonicIEF method enables faster mobilization and reduces total fractionation time by approximately 40 minutes.
Application Note: Rapid Analysis for High-Throughput Antibody Development
This application note describes a workflow for recombinant antibodies that were produced on a HT platform, purified, and then analyzed for charge heterogeneity with icIEF and CE-SDS. Both methods resolved distinct peaks in all antibodies, signifying important structural properties that could potentially influence the selection process.
Application Note: Rapid and High-Quality Analysis of Therapeutic Fusion Proteins with Maurice Turbo CE-SDS Cartridge
Explore how the Turbo CE-SDS method on the Maurice system provides a fast, reliable, and label-free approach for analyzing fusion proteins like Etanercept, with excellent linearity and reproducibility, facilitating high-throughput applications while ensuring data quality.
eBook: Advancing the Analysis of Next Generation Biotherapeutics
Access our eBook to learn about advancements in the analysis of next-generation biotherapeutics (ADCs, bispecific antibodies, fusion proteins, LNPs and AAVs) using CE technologies. Learn how charge variant fractionation, when combined with downstream techniques such as high-resolution LC-MS, mass photometry and SPR, have accelerated workflows, improved sensitivity, and enabled deeper characterization of these complex molecules.
Accelerating Lead Identification Through Integrated Antibody Development and Characterization
This webinar demonstrates a scalable workflow to express and purify ~100 recombinant antibodies in a single run, an improved approach to CHO‑K1 cell line development using the TcBuster® transposon system, delivering significantly higher antibody titers and more productive clones, and high‑resolution biophysical methods using icIEF and CE-SDS techniques to rapidly assess size, purity, and charge heterogeneity—critical quality attributes that enable confident lead selection early in development. Together, these strategies provide an integrated path from antibody discovery to developable, manufacturable candidates—faster and with greater confidence.
SupersonicIEF Method for Faster Charge Heterogeneity Analysis
This webinar describes strategies to improve productivity and throughput for charge variant analysis. Will McElroy (Bio-Techne) shares details on the development of the SupersonicIEF method, which significantly reduces overall analysis time while preserving data quality, offering a practical solution for accelerating biotherapeutic characterization. Dr. Michael Grasso (Merck) describes the successful implementation and positive impact of this new method on the analysis of four different biotherapeutic classes (mAbs, Fc Fusion proteins, Bispecifics, and ADCs), demonstrating use cases where this faster method can improve resolution comppared to the standard method.
Let's Meet Up
- IMSC 2026 – August 22-28, 2026 (Lyon, France)
- CASSS CE Pharm Conference – September 28-30, 2026 (Rockville, MD)
- Boston User Meeting (Cambridge) – October 14, 2026
- World ADC Conference – October 12-15, 2026
- Advanced Protein Characterization Workshop, co-hosted with A&M Stabtest - October 15, 2026 (Bergheim, Germany)
- Philadelphia User Meeting (KOP) – October 20, 2026
- New Jersey User Meeting (Plainsboro) – October 22, 2026
Schedule a Biologics Bitesize Tech Talk
Do you want to learn about the latest applications for the Maurice and MauriceFlex platforms - but don't have much time? We’re happy to host lunch or a break at your convenience to discuss the topics of most interest to your lab. Choose from our menu of 15-minute bitesize talks to discover what’s new in the areas of biomolecular-specific analysis, icIEF fractionation, CE-SDS, Gene Therapy, and more!
Choose from a full menu of topics.
Maximizing Throughput with Advanced Maurice Cartridges and Methods
In her training series “Technical Tips from Monica Tyagi,” Dr. Tyagi discusses some simple but important methods and cartridges can significantly improve productivity using the Maurice platform for charge and size analysis using icIEF, icIEF-fractionation and CE-SDS.
From Your Peers
“If we think back to our method goals, one of the key pieces is that the assay needs to be high throughput. Our question was: Can you utilize the faster run time with the Turbo CE-SDS Cartridge without losing the resolution and separation of the homodimer and the heterodimer [from the CE-SDS Plus cartridge]? The results in fact, were very comparable… and we had the added benefit of reducing the run time from 50 minutes to 15 minutes.
The next step was incorporating [the Turbo CE-SDS Cartridge] into process development. We were able to support the entirety of process development from clone selection through downstream fractionation. We also tested linearity, repeatability, and accuracy, proving it can be used for GMP release and stability testing.” - Caroline Daniels, Shattuck Labs
Test your knowledge on improving productivity with Maurice Platforms and enter for a chance to win a mug. Complete our short quiz using information from Volume 2, Issue 4 of CE Chronicles.
