1,2,3,4,5,6-Hexabromocyclohexane

Key Product Details

Product Description

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.

Product Specifications for 1,2,3,4,5,6-Hexabromocyclohexane

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 1,2,3,4,5,6-Hexabromocyclohexane

The following data is based on the product molecular weight 557.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.94 mL	89.68 mL	179.36 mL
0.5 mM	3.59 mL	17.94 mL	35.87 mL
1 mM	1.79 mL	8.97 mL	17.94 mL
5 mM	0.36 mL	1.79 mL	3.59 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Sandberg Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation. J.Med.Chem. 2005 PMID: 15801842

Product Documents for 1,2,3,4,5,6-Hexabromocyclohexane