1-Methyl-D-tryptophan

Key Product Details

Product Description

1-Methyl-D-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Product Specifications for 1-Methyl-D-tryptophan

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 1-Methyl-D-tryptophan

The following data is based on the product molecular weight 218.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	91.64 mL	458.19 mL	916.38 mL
0.25 mM	18.33 mL	91.64 mL	183.28 mL
0.5 mM	9.16 mL	45.82 mL	91.64 mL
2.5 mM	1.83 mL	9.16 mL	18.33 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Rytelewski Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 2014 PMID: 24587363
• Nakamura Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 2015 PMID: 26243621

Product Documents for 1-Methyl-D-tryptophan