10-Cl-BBQ

Key Product Details

Product Description

10-Cl-BBQ is a potent aryl hydrocarbon receptor (AhR) agonist, discovered as a screening hit (IC₅₀ = 2.6 nM). Directly binds CD4⁺ T cells to induce AhR-dependent Tregs. Suppresses IL-17 production and prevents insulitis in NOD mice. In vivo half llife ~ 2 hours, orally bioavailable.

Product Specifications for 10-Cl-BBQ

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 10-Cl-BBQ

The following data is based on the product molecular weight 304.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.01 mM	328.16 mL	1,640.80 mL	3,281.59 mL
0.05 mM	65.63 mL	328.16 mL	656.32 mL
0.1 mM	32.82 mL	164.08 mL	328.16 mL
0.5 mM	6.56 mL	32.82 mL	65.63 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ehrlich Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3+ regulatory T Cells in nonobese diabetic mice. J.Immunol. 2016 PMID: 26573835
• Punj Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One 2014 PMID: 24586378

Product Documents for 10-Cl-BBQ