Product Description
193 D7 is a histone demethylase JMJD1C inhibitor (IC50 = 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumor by targeting intratumoral Treg cells in mice tumor models. 193 D7 is orally bioavailable.
Product Specifications for 193 D7
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.74 | 100 | |
| Ethanol | 6.35 | 20 |
Preparing Stock Solutions for 193 D7
The following data is based on the product molecular weight 317.36.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.75 mL | 31.51 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.30 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Background References
References are publications that support the biological activity of the product.
- Long Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity. Nat.Immunol. 2024 PMID: 38356061
Product Documents for 193 D7
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for 193 D7
For research use only
Related Research Areas
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