2-Cl-IB-MECA

Tocris Bioscience | Catalog # 1104

Highly selective A3 agonist
Tocris Bioscience

Key Product Details

Description

Highly selective A3 agonist
View all Adenosine A3 Receptor Agonists »

Product Description

2-Cl-IB-MECA is a high affinity and extremely selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. Exhibits high selectivity over the Na+-independent adenosine transporter.

Licensing Information

Sold with the permission of the NIH, US Patent 08/091,109

Product Specifications for 2-Cl-IB-MECA

Molecular Weight

544.74

Formula

C18H18ClIN6O4

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide

CAS Number

163042-96-4

PubChem ID

3035850

InChI Key

IPSYPUKKXMNCNQ-PFHKOEEOSA-N

SMILES

O[C@@H]1[C@@H]([C@](NC)=O)O[C@@H](N(C=N4)C2=C4C(NCC3=CC(I)=CC=C3)=NC(Cl)=N2)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions for 2-Cl-IB-MECA

The following data is based on the product molecular weight 544.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.18 mL 18.36 mL
5 mM 0.37 mL 1.84 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 60 publications citing the usage of this product.

Product Documents for 2-Cl-IB-MECA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 2-Cl-IB-MECA

For research use only

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    Verified Customer | Posted 12/01/2017
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