25-Hydroxycholesterol

Key Product Details

Product Description

25-Hydroxycholesterol is an antiviral. Stimulates expression of miR-185 microRNA which inhibits the hepatitis C virus life cycle via inhibition of cholesterol biosynthesis and virus cell membrane fusion. Also α-crystallin (cryAB) chaperone (K_d = 10.1 μM). Blocks α-crystallin aggregation and partially reverses cataract formation by binding and stabilizing soluble forms of cryAB in vitro and in vivo.

Product Specifications for 25-Hydroxycholesterol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 25-Hydroxycholesterol

The following data is based on the product molecular weight 402.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.42 mL	62.09 mL	124.18 mL
1 mM	2.48 mL	12.42 mL	24.84 mL
2 mM	1.24 mL	6.21 mL	12.42 mL
10 mM	0.25 mL	1.24 mL	2.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Makley Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models. Science 2015 PMID: 26542570
• Singaravelu MicroRNAs regulate the immunometabolic response to viral infection in the liver. Nat.Chem.Biol. 2015 PMID: 26479438

Product Documents for 25-Hydroxycholesterol