3-MATIDA

Key Product Details

Product Description

Potent metabotropic glutamate mGlu₁ receptor antagonist (IC₅₀ = 6.3 μM at rat mGlu_1a). Displays ≥ 40-fold selectivity over other receptors: mGlu₅, mGlu₂, mGlu_4a (IC₅₀ > 300 μM), NMDA and AMPA (IC₅₀ = 250 μM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.

Product Specifications for 3-MATIDA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 3-MATIDA

The following data is based on the product molecular weight 215.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.65 mL	23.23 mL	46.46 mL
5 mM	0.93 mL	4.65 mL	9.29 mL
10 mM	0.46 mL	2.32 mL	4.65 mL
50 mM	0.09 mL	0.46 mL	0.93 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Cozzi Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity? Neuropharmacology 2002 PMID: 12213266
• Constantino Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist. Il Farmaco 2004 PMID: 14871500
• Moroni The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology 2002 PMID: 12015200

Product Documents for 3-MATIDA