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4BP-TQS

Catalog #: 4234
1 Citation Datasheet / COA / SDS

Discontinued Product

4234 has been discontinued.
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4BP-TQS | CAS No. 360791-49-7 | Nicotinic (a7) Receptor Agonists
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Description: α7 nAChR agonist; acts at an allosteric site

Chemical Name: 4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

4BP-TQS is an allosteric agonist at α7 nAChR. Binds at a separate site and exhibits more efficacious receptor agonism compared to acetylcholine (Cat. No. 2809), displays 8-fold lower EC50 value and 45-fold larger maximal response.

Technical Data

M.Wt:
405.31
Formula:
C18H17BrN2O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
360791-49-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
    Gill et al.
    Proc.Natl.Acad.Sci.U.S.A., 2011;108:5867

Product Datasheets

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Citation for 4BP-TQS

The citations listed below are publications that use Tocris products. Selected citations for 4BP-TQS include:

1 Citation: Showing 1 - 1

  1. Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.
    Authors: Zhang Et al.
    Proc Natl Acad Sci U S A  2015;10:e0137588

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