5-Amino-Thalidomide

Tocris Bioscience | Catalog # 7678

Cereblon ligand with amine on C5 for onward chemistry
Tocris Bioscience

Key Product Details

Description

Cereblon ligand with amine on C5 for onward chemistry
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Product Description

5-Amino-Thalidomide is a functionalized cereblon (CRBN) ligand for PROTAC® research and development; incorporates an E3 ligase ligand with an amine on the C5 position of the phthalimide ring for onward chemistry to generate Protein Degraders with rigid linkers. Degraders with modifications on the C5 position reduce off-target zinc-finger proteins degradation.

Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for 5-Amino-Thalidomide

Molecular Weight

273.24

Formula

C13H11N3O4

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

5-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

CAS Number

191732-76-0

InChI Key

IICWMVJMJVXCLY-UHFFFAOYSA-N

SMILES

O=C1C2=CC=C(N)C=C2C(=O)N1C3C(=O)NC(=O)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

  • Nguyen Proteolysis Targeting Chimeras With Reduced Off-targets. bioRxiv

Product Documents for 5-Amino-Thalidomide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 5-Amino-Thalidomide

For research use only

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