6-Chloromelatonin
Discontinued Product
Chemical Name: N-[2-(6-Chloro-5-methoxyindol-3-yl)ethyl]acetamide
Purity: ≥99%
Biological Activity
6-Chloromelatonin is a potent melatonin agonist (pKi values are 9.10 and 9.77 for human recombinant MT1 and MT2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors.
Browning et al.
Br.J.Pharmacol., 2000;129:877 -
Luzindole (NO 774): a novel melatonin receptor antagonist.
Dubocovich
J.Pharmacol.Exp.Ther., 1988;246:902 -
Melatonin receptors: are there multiple subtypes?
Dubocovich
TiPS, 1995;16:50 -
2-[125I]Iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution.
Duncan et al.
Endocrinology, 1988;122:1825
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