6-Chloromelatonin

Key Product Details

Product Description

6-Chloromelatonin is a potent melatonin agonist (pK_i values are 9.10 and 9.77 for human recombinant MT₁ and MT₂ receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.

Product Specifications for 6-Chloromelatonin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 6-Chloromelatonin

The following data is based on the product molecular weight 266.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.75 mL	37.49 mL
5 mM	0.75 mL	3.75 mL	7.50 mL
10 mM	0.37 mL	1.87 mL	3.75 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Duncan 2-[¹²⁵I]Iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinology 1988 PMID: 2834175
• Dubocovich Luzindole (NO 774): A novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 1988 PMID: 2843633
• Dubocovich Melatonin receptors: are there multiple subtypes? TiPS 1995 PMID: 7762083
• Browning Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors. Br.J.Pharmacol. 2000 PMID: 10696085

Product Documents for 6-Chloromelatonin