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6-Mercaptopurine

Catalog #: 4103
1 Citation Datasheet / COA / SDS

Discontinued Product

4103 has been discontinued.
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6-Mercaptopurine | CAS No. 50-44-2 | DNA, RNA and Protein Synthesis Inhibitors
1 Image
Description: Purine analog; inhibits DNA and RNA synthesis

Chemical Name: Purine-6(1H)-thione

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

6-Mercaptopurine is an inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite of azathioprine (Cat. No. 4099). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 21.6 μM for PLpro deubiquitination activity).

Technical Data

M.Wt:
152.18
Formula:
C5H4N4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH
Purity:
≥99%
Storage:
Store at RT
CAS No:
50-44-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Clinical pharmacology and pharmacogenetics of thiopurines.
    Sahasranaman et al.
    Eur.J.Clin.Pharmacol., 2008;64:753

Product Datasheets

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Reconstitution Calculator

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Citation for 6-Mercaptopurine

The citations listed below are publications that use Tocris products. Selected citations for 6-Mercaptopurine include:

1 Citation: Showing 1 - 1

  1. Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.
    Authors: Ari Et al.
    iScience  2021;24:102651

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