6-Thioguanine

Tocris Bioscience | Catalog # 4061

Anticancer and immunosuppressive agent
Tocris Bioscience
Discontinued Product
4061 has been discontinued. View all Immunosuppressants products.

Key Product Details

Description

Anticancer and immunosuppressive agent

Alternative Names

6-TG
View all Immunosuppressants »

Product Description

6-Thioguanine is an anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 5 μM for PLpro deubiquitination activity).

Product Specifications for 6-Thioguanine

Molecular Weight

167.19

Formula

C5H5N5S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-Amino-6-mercaptopurine

CAS Number

154-42-7

PubChem ID

2723601

InChI Key

WYWHKKSPHMUBEB-UHFFFAOYSA-N

SMILES

NC1=NC(S)=C2C(NC=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.72 100

Preparing Stock Solutions for 6-Thioguanine

The following data is based on the product molecular weight 167.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.98 mL 29.91 mL 59.81 mL
5 mM 1.20 mL 5.98 mL 11.96 mL
10 mM 0.60 mL 2.99 mL 5.98 mL
50 mM 0.12 mL 0.60 mL 1.20 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for 6-Thioguanine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 6-Thioguanine

For research use only

⚠ WARNING: This product can expose you to chemicals including Thioguanine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Customer Reviews for 6-Thioguanine (1)

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  • The effects of 6-thioguanine on growth and metabolism
    Name: Matthew Dempley
    Species: Human
    Verified Customer | Posted 12/02/2019
    6-Thioguanine was incorporated into the RNA of all subcellular fractions, but to different extents and it also appears to be incorporated into a non-nucleotide fraction in the cell walk.
    6-Thioguanine 4061

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