7α,25-Dihydroxycholesterol

Key Product Details

Product Description

7α,25-Dihydroxycholesterol is a highly potent GPR183 (EBI2) agonist (EC₅₀ = 140 pM) and putative natural ligand for GPR183. Regulates migration of B and T cells expressing GPR183 in vivo. Desensitizes B cells and reduces their movement to splenic follicles.

Product Specifications for 7α,25-Dihydroxycholesterol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 7α,25-Dihydroxycholesterol

The following data is based on the product molecular weight 418.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.89 mL	119.43 mL	238.86 mL
0.5 mM	4.78 mL	23.89 mL	47.77 mL
1 mM	2.39 mL	11.94 mL	23.89 mL
5 mM	0.48 mL	2.39 mL	4.78 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hannedouche Oxysterols direct immune cell migration via EBI2. Nature. 2011 PMID: 21796212
• Liu Oxysterols direct B-cell migration through EBI2. Nature. 2011 PMID: 21796211

Product Documents for 7α,25-Dihydroxycholesterol