7rh

Key Product Details

Product Description

7rh is a potent and selective DDR1 inhibitor (IC₅₀ = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC₅₀ values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable.

Product Specifications for 7rh

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 7rh

The following data is based on the product molecular weight 546.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.83 mL	9.15 mL	18.30 mL
5 mM	0.37 mL	1.83 mL	3.66 mL
10 mM	0.18 mL	0.91 mL	1.83 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Gao Discovery and optimization of 3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J.Med.Chem. 2013 PMID: 23521020

Product Documents for 7rh