8-Aminoadenine

Key Product Details

Product Description

8-Aminoadenine is an adenine receptor agonist (K_i = 0.0341 μM in HEK293 cells expressing an adenine binding site). Displays 190-fold increased potency at the human binding site over the rat adenine receptor (rAde1R) (K_i = 6.51 μM).

Product Specifications for 8-Aminoadenine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 8-Aminoadenine

The following data is based on the product molecular weight 150.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.66 mL	33.30 mL	66.60 mL
5 mM	1.33 mL	6.66 mL	13.32 mL
10 mM	0.67 mL	3.33 mL	6.66 mL
50 mM	0.13 mL	0.67 mL	1.33 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bender Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci.
• Borrmann Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. J.Med.Chem. 2009 PMID: 19731917

Product Documents for 8-Aminoadenine