968

Key Product Details

Product Description

968 is an allosteric inhibitor of glutaminase. Blocks Rho-GTPase-dependent transformation of fibroblasts. Suppresses breast cancer cell growth and invasive activity in vitro. Also inhibits P-493 B lymphoma cell growth and reduces tumor size of P-493 cell xenografts in mice.

Product Specifications for 968

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 968

The following data is based on the product molecular weight 475.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.52 mL	52.59 mL	105.17 mL
1 mM	2.10 mL	10.52 mL	21.03 mL
2 mM	1.05 mL	5.26 mL	10.52 mL
10 mM	0.21 mL	1.05 mL	2.10 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Stalnecker Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 2015 PMID: 25548170
• Lu Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell 2010 PMID: 20832746
• Wang Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 2010 PMID: 20832749

Product Documents for 968