A 1899

Key Product Details

Product Description

A 1899 is a potent K_2P3.1 (TASK-1) and K_2P9.1 (TASK-3) channel blocker (IC₅₀ values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K⁺ channels (IC₅₀ = 0.9 μM for K_2P18.1/TRESK and >2 μM for all other channels tested). Binds within open channel pore.

Product Specifications for A 1899

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 1899

The following data is based on the product molecular weight 500.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.98 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Streit A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J.Biol.Chem. 2011 PMID: 21362619

Product Documents for A 1899