A 286982

Tocris Bioscience | Catalog # 4228

Potent inhibitor of the LFA-1/ICAM-1 interaction
Tocris Bioscience

Key Product Details

Description

Potent inhibitor of the LFA-1/ICAM-1 interaction
View all Integrin Receptor Inhibitors »

Product Description

A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).

Product Specifications for A 286982

Molecular Weight

453.55

Formula

C24H27N3O4S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one

CAS Number

280749-17-9

PubChem ID

9846729

InChI Key

HTGGAYLWTDOFDK-PKNBQFBNSA-N

SMILES

O=C(C)N1CCN(C(/C=C/C2=CC([N+]([O-])=O)=C(SC3=CC=CC=C3C(C)C)C=C2)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.35 100
Ethanol 22.68 50

Preparing Stock Solutions for A 286982

The following data is based on the product molecular weight 453.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.20 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.20 mL 4.41 mL
10 mM 0.22 mL 1.10 mL 2.20 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for A 286982

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 286982

For research use only

Customer Reviews for A 286982 (1)

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  • A 286982 was used to inhibit the action of LFA-1 ( alpha L beta 2) and measure effects
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/26/2019
    alpha L beta 2 is crucial for lymphocyte adhesion and costimulation. We worked to determine alpha L beta 2's role in leukocyte adhesion to and migration through endothelium by its ability to bind intercellular adhesion molecules (ICAMs). A 286982 was used to inhibit the action and measure effects.
    A 286982 4228

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