A 410099.1

Tocris Bioscience | Catalog # 6470

High affinity XIAP antagonist; active in vivo
Tocris Bioscience

Key Product Details

Description

High affinity XIAP antagonist; active in vivo
View all IAP Inhibitors »

Product Description

A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.

Product Specifications for A 410099.1

Molecular Weight

505.09

Formula

C27H40N4O3.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride

CAS Number

762274-58-8

PubChem ID

131858992

InChI Key

OPCYOBWCDDJCFT-VOSOYEAFSA-N

SMILES

CN[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)=O)C4CCCCC4)=O)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50.51 100
DMSO 50.51 100

Preparing Stock Solutions for A 410099.1

The following data is based on the product molecular weight 505.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.90 mL 19.80 mL
5 mM 0.40 mL 1.98 mL 3.96 mL
10 mM 0.20 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for A 410099.1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 410099.1

For research use only

Related Research Areas

Cysteine Proteases and Regulators

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