A 484954

Key Product Details

Product Description

A 484954 is an inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC₅₀ = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.

Product Specifications for A 484954

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 484954

The following data is based on the product molecular weight 289.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.57 mL	172.84 mL	345.67 mL
0.5 mM	6.91 mL	34.57 mL	69.13 mL
1 mM	3.46 mL	17.28 mL	34.57 mL
5 mM	0.69 mL	3.46 mL	6.91 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Chen 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 2011 PMID: 22020937

Product Documents for A 484954