A 582941

Key Product Details

Product Description

A 582941 is a selective α7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (K_i values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT₃ receptors (K_i = 150 nM for 5-HT₃).

Product Specifications for A 582941

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 582941

The following data is based on the product molecular weight 280.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.57 mL	17.83 mL	35.67 mL
5 mM	0.71 mL	3.57 mL	7.13 mL
10 mM	0.36 mL	1.78 mL	3.57 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Anderson [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain J.Pharmacol.Exp.Ther. 2008 PMID: 17959745

Product Documents for A 582941