A 80426 mesylate

Key Product Details

Product Description

A 80426 mesylate is a high affinity α₂-adrenoceptor antagonist and selective 5-HT uptake inhibitor (K_i values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.

Product Specifications for A 80426 mesylate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 80426 mesylate

The following data is based on the product molecular weight 445.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.22 mL	22.44 mL
5 mM	0.45 mL	2.24 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Giardina A-80426, a potent and selective β₂-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile. Drug Devel.Res.
• Meyer Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition. Bioorg.Med.Chem.Letts.

Product Documents for A 80426 mesylate