A 922500

Key Product Details

Product Description

A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC₅₀ values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo. Orally active.

Product Specifications for A 922500

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 922500

The following data is based on the product molecular weight 428.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.67 mL	23.34 mL	46.68 mL
2.5 mM	0.93 mL	4.67 mL	9.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
25 mM	0.09 mL	0.47 mL	0.93 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• King Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the zucker fatty rat and the hyperlipidemic hamster. J.Pharmacol.Exp.Ther. 2009 PMID: 19478132
• King In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia. Eur.J.Pharmacol. 2010 PMID: 20385122
• Zhao Validation of diacyl glycerolacyltransferase I as a novel target of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J.Med.Chem. 2008 PMID: 18183944

Product Documents for A 922500