A 967079

Tocris Bioscience | Catalog # 4716

Selective TRPA1 channel blocker
Tocris Bioscience

Key Product Details

Description

Selective TRPA1 channel blocker

Alternative Names

A-079
View all TRPA1 Blockers »

Product Description

A 967079 (also known as A-079) is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively) that displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. A 967079 exhibits analgesic effects in a rat osteoarthritic pain model.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A 967079 (A-079) is reviewed.

Product Specifications for A 967079

Molecular Weight

207.24

Formula

C12H14FNO

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime

CAS Number

1170613-55-4

PubChem ID

42641861

InChI Key

HKROEBDHHKMNBZ-CHBKHGQFSA-N

SMILES

FC1=CC=C(/C=C(C)/C(CC)=N/O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 100
Ethanol 20.72 100

Preparing Stock Solutions for A 967079

The following data is based on the product molecular weight 207.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.13 mL 48.25 mL
5 mM 0.97 mL 4.83 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.10 mL 0.48 mL 0.97 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 47 publications citing the usage of this product.

Product Documents for A 967079

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 967079

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for A 967079 (1)

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  • Blocking TRPA1 function in chronic itch
    Name: Jing Feng
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 01/04/2018
    It may be a little difficult to dissolve the drug at a higher concentration.
    A967079 was used in the animal behavior test to block the TRPA1-mediated chronic itch at the concentration of 10mg/Kg
    A 967079 4716

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