AAQ chloride

Key Product Details

Product Description

AAQ chloride is a photoswitchable K_v channel blocker (IC₅₀ values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Na_v1.2 and L-type Ca²⁺ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.

Licensing Information

Sold under license from Photoswitch Biosciences, Inc.

Product Specifications for AAQ chloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AAQ chloride

The following data is based on the product molecular weight 443.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.26 mL	56.31 mL	112.62 mL
1 mM	2.25 mL	11.26 mL	22.52 mL
2 mM	1.13 mL	5.63 mL	11.26 mL
10 mM	0.23 mL	1.13 mL	2.25 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Polosukhina Photochemical restoration of visual responses in blind mice. Neuron 2012 PMID: 22841312
• Banghart Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 2009 PMID: 19882609
• Fortin Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 2008 PMID: 18311146

Product Documents for AAQ chloride