ABP 688

Key Product Details

Product Description

ABP 688 is a high affinity human mGlu₅ receptor antagonist (K_i = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu₅ receptors (IC₅₀ = 2.3 nM).

Product Specifications for ABP 688

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ABP 688

The following data is based on the product molecular weight 240.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.16 mL	20.81 mL	41.61 mL
5 mM	0.83 mL	4.16 mL	8.32 mL
10 mM	0.42 mL	2.08 mL	4.16 mL
50 mM	0.08 mL	0.42 mL	0.83 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Hintermann ABP688, a novel selective and high affinity ligand for the labeling of mGlu₅ receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 2007 PMID: 17110115

Product Documents for ABP 688