AC 253

Name: AC 253
Brand: Tocris Bioscience
SKU: 6550

Tocris Bioscience | Catalog # 6550

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Product Documents

Amylin (AMY3) antagonist

Discontinued Product

6550 has been discontinued. View all Calcitonin and Related Receptor Agonists products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Amylin (AMY3) antagonist

View all Calcitonin and Related Receptor Agonists »

Product Description

AC 253 is an amylin (AMY₃) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca²⁺, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Aβ in vitro. Cyclic AC 253 (Cat.No. 6550) also available.

Product Specifications for AC 253

Molecular Weight

2847.11

Formula

C₁₂₂H₁₉₆N₄₀O₃₉

Storage

Store at -20°C

CAS Number

151804-79-4

PubChem ID

134160251

InChI Key

QOVDFCPGVUGNIP-MLZIZKOLSA-N

SMILES

CC(C)C[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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音量

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Background References

References are publications that support the biological activity of the product.

Jhamandas Actions of β-amyloid protein on human neurons are expressed through the amylin receptor. Am.J.Pathol. 2011 PMID: 21224052
Fu Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J,Biol.Chem. 2012 PMID: 22500019
Coppock Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem.J. 1999 PMID: 9931292

Product Documents for AC 253

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for AC 253

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Osteoblast and Osteoclast Markers

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