AC 265347

Key Product Details

Product Description

AC 265347 is a CaSR biased allosteric modulator (pEC₅₀ = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP₁. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABA_B or type I PTH receptors. Orally active.

Product Specifications for AC 265347

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AC 265347

The following data is based on the product molecular weight 283.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.53 mL	17.64 mL	35.29 mL
5 mM	0.71 mL	3.53 mL	7.06 mL
10 mM	0.35 mL	1.76 mL	3.53 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ma Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 2011 PMID: 21239511
• Leach Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell.Res. 2016 PMID: 27002221
• Cook Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. Br.J.Pharmacol. 2015 PMID: 25220431

Product Documents for AC 265347