Ac9-25
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Description: Annexin I N-terminal peptide; acts as a FPR1 ligand
Biological Activity
Ac9-25 is a N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.Technical Data
M.Wt:
2183.35
Formula:
C99H143N23O33
Sequence:
QAWFIENEEQEYVQTVK
(Modifications: Gln-1 = N-terminal amide)
Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Desiccate at -20°C
CAS No:
284040-76-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR.
Walther et al.
Mol.Cell, 2000;5:831 -
The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview.
Rabiert et al.
Biochimie, 2007;89:1089 -
Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors.
Karlsson et al.
J.Leuko.Biol., 2005;78:762
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