Ac9-25

Name: Ac9-25
Brand: Tocris Bioscience
SKU: 3231

Tocris Bioscience | Catalog # 3231

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Product Documents

Annexin I N-terminal peptide; acts as a FPR1 ligand

Discontinued Product

3231 has been discontinued. View all Formyl Peptide Receptor Ligands products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Annexin I N-terminal peptide; acts as a FPR1 ligand

View all Formyl Peptide Receptor Ligands »

Product Description

Ac9-25 is a N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.

Product Specifications for Ac9-25

Molecular Weight

2183.35

Formula

C₉₉H₁₄₃N₂₃O₃₃

Storage

Desiccate at -20°C

CAS Number

284040-76-2

PubChem ID

90488817

InChI Key

VWAGQOJTUDBVPD-ZONPJGGESA-N

SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 20% acetonitrile / water

Calculators

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Mass

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Concentration 1 (C1)

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Background References

References are publications that support the biological activity of the product.

Rabiert The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview. Biochimie 2007 PMID: 17428601
Karlsson Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol.
Walther A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol.Cell 2000 PMID: 10882119

Product Documents for Ac9-25

Certificate of Analysis

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Product Specific Notices for Ac9-25

For research use only

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