Acetaminophen

Key Product Details

Product Description

Acetaminophen is a cyclooxygenase inhibitor; may be selective for COX-3 (IC₅₀ values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.

Product Specifications for Acetaminophen

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Acetaminophen

The following data is based on the product molecular weight 151.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.62 mL	33.08 mL	66.16 mL
5 mM	1.32 mL	6.62 mL	13.23 mL
10 mM	0.66 mL	3.31 mL	6.62 mL
50 mM	0.13 mL	0.66 mL	1.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

• Chong Effect of acetaminophen on atherosclerosis. Ann.Pharmacother. 2001 PMID: 11724102
• Riendeau Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can.J.Physiol.Pharmacol. 1997 PMID: 9365818
• Chandrasekharan COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc.Natl.Acad.Sci.U.S.A. 2002 PMID: 12242329

Product Documents for Acetaminophen