Acetyl Pepstatin
Discontinued Product
Biological Activity
Acetyl Pepstatin is a high affinity aspartic protease inhibitor. Inhibits HIV-1 protease (Ki = 20 nM at pH 4.7) and HIV-2 protease (Ki = 5 nM at pH 4.7). Antiviral.Technical Data
(Modifications: Val-1 = N-terminal Ac, Val-2 = Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-(3S,4S)4-amino-3-hydroxy-6-methylheptanoic-acid)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin.
Mat?z et al.
FEBS J., 2012;279:3276 -
Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases.
Richards et al.
FEBS Lett., 1989;247:113 -
Inhibition of the aspartic proteinase from HIV-2.
Richards et al.
FEBS Lett., 1989;253:214
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