Acifran

Key Product Details

Product Description

Acifran is a hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC₅₀ values are 1.3 and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.

Product Specifications for Acifran

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Acifran

The following data is based on the product molecular weight 218.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.58 mL	22.91 mL	45.83 mL
5 mM	0.92 mL	4.58 mL	9.17 mL
10 mM	0.46 mL	2.29 mL	4.58 mL
50 mM	0.09 mL	0.46 mL	0.92 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wise Molecular identification of high and low affinity receptors for nicotinic acid. J.Biol.Chem. 2003 PMID: 12522134
• Jirkovsky and Cayen Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. J.Med.Chem. 1982 PMID: 7143351
• Jung Analogues of acrifan: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J.Med.Chem. 2007 PMID: 17358052
• Cayen Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis 1982 PMID: 6818976

Product Documents for Acifran