ACT 335827

Key Product Details

Product Description

ACT 335827 is a potent and selective orexin OX₁ receptor antagonist (K_b values are 41 and 560 nM for OX₁ and OX₂ receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.

Product Specifications for ACT 335827

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ACT 335827

The following data is based on the product molecular weight 518.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.93 mL	9.64 mL	19.28 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
10 mM	0.19 mL	0.96 mL	1.93 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Steiner Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist. ChemMedChem 2013 PMID: 23589487

Product Documents for ACT 335827