Adapalene

Key Product Details

Product Description

Adapalene is a retinoic acid analog that is a RARβ and RARγ agonist (AC₅₀ values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.

Product Specifications for Adapalene

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Adapalene

The following data is based on the product molecular weight 412.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.70 mL	48.48 mL	96.96 mL
1.25 mM	1.94 mL	9.70 mL	19.39 mL
2.5 mM	0.97 mL	4.85 mL	9.70 mL
12.5 mM	0.19 mL	0.97 mL	1.94 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Millikan Adapalene: an update on newer comparative studies between the various retinoids. Int.J.Dermatol. 2000 PMID: 11095202
• Ocker The synthetic retinoid adap. inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Int.J.Cancer 2003 PMID: 14506747
• Shroot Pharmacology and chemistry of adap. J.Am.Acad.Dermatol. 1997 PMID: 9204085

Product Documents for Adapalene