Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Tocris Bioscience | Catalog # 3633

Ecto-5'-nucleotidase (CD73) inhibitor
Tocris Bioscience
Discontinued Product
3633 has been discontinued. An alternative/replacement product is available: 8173. View all NTPDase Inhibitors products.

Key Product Details

Description

Ecto-5'-nucleotidase (CD73) inhibitor

Alternative Names

AMPCP,APCP
View all NTPDase Inhibitors »

Product Description

Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.

Product Specifications for Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Molecular Weight

447.21

Formula

C11H16N5NaO9P2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

α,β-Methyleneadenosine 5'-diphosphate monosodium salt

CAS Number

89016-30-8

PubChem ID

91691113

InChI Key

RFGZKSPLJPHQMI-RDJRRFHDSA-M

SMILES

NC1=C2C(N([C@@H]3O[C@H](COP(CP(O)(O[Na])=O)(O)=O)[C@@H](O)[C@@H]3O)C=N2)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Adenosine 5'-(α,β-methylene)diphosphate sodium salt

For research use only

Citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Customer Reviews for Adenosine 5'-(α,β-methylene)diphosphate sodium salt (1)

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  • Inhibited CD73 activity in TCRgd T cells completely
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 06/05/2018
    Perfect for inhibiting CD73 activity in TCRgd T cells. TCRgd T cells express enzymatically active CD73 on their surface. CD73 activity was detected by the converting of AMP to adenosine which was completely blocked by APCP.
    Adenosine 5'-(α,β-methylene)diphosphate sodium salt 3633

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