Adrenomedullin R/ADMR/GPR182 Antibody (S02-3E6)

Novus Biologicals | Catalog # NBP3-19650

Recombinant Monoclonal Antibody
Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-3E6 expressed in HEK293
View all Adrenomedullin R/ADMR Primary Antibodies »

Product Specifications

Immunogen

Recombinant protein of human Adrenomedullin R/ADMR/GPR182 (Uniprot # O15218)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Adrenomedullin R/ADMR/GPR182 Antibody (S02-3E6)

Western Blot: Adrenomedullin R/ADMR/GPR182 Antibody (S02-3E6) [NBP3-19650]

Western Blot: Adrenomedullin R/ADMR/GPR182 Antibody (S02-3E6) [NBP3-19650]

Western Blot: Adrenomedullin R/ADMR/GPR182 Antibody (S02-3E6) [NBP3-19650] - Western blot detection of Adrenomedullin R/ADMR/GPR182 in K562, C6, 3T3, Hela cell lysates using NBP3-19650 (1:1000 diluted). Predicted band size: 45kDa. Observed band size: 45kDa.

Applications for Adrenomedullin R/ADMR/GPR182 Antibody (S02-3E6)

Application
Recommended Usage

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Adrenomedullin R/ADMR

G Protein-Coupled Receptor L1/G10D has been suggested to be an Adrenomedullin Receptor. Originally cloned from rats and later from humans, L1/G10D does not to bind adrenomedullin or display functional cAMP response to adrenomedullin (reviewed in Poyner et al. 2002). The initial experimental results, which demonstrated high-affinity binding and increased levels of cAMP in COS cells that were transfected with L1/G10D and treated with adrenomedullin, could not be reproduced by other laboratories (Kapas et al. 1995). It is now known that the functional adrenomedullin receptor is a heterodimeric complex composed of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) (McLatchie et al. 1998). L1/G10D therefore should be considered an Orphan A receptor. L1/G10D expression has been reported in adrenal gland, bone marrow, brain, heart, kidney, liver, lung, lymph node, pancreas, skeletal muscle, small intestine, spleen, stomach, testis, and thyroid. ESTs have been isolated from kidney, liver/spleen, fetal lung/testis/B-cell, and melanocyte/uterus/fetal heart libraries.

Long Name

Adrenomedullin Receptor

Alternate Names

7TMR, ADMR, AdrenomedullinR, AMR, G10D, GAMRH, Gpcr22, GPR182, MB10, NOW

Gene Symbol

GPR182

Additional Adrenomedullin R/ADMR Products

Product Documents for Adrenomedullin R/ADMR/GPR182 Antibody (S02-3E6)

Certificate of Analysis

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Product Specific Notices for Adrenomedullin R/ADMR/GPR182 Antibody (S02-3E6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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