AEG 3482

Tocris Bioscience | Catalog # 2651

Inhibitor of JNK signaling
Tocris Bioscience
Discontinued Product
2651 has been discontinued. View all JNK/c-jun Inhibitors products.

Key Product Details

Description

Inhibitor of JNK signaling
View all JNK/c-jun Inhibitors »

Product Description

AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).

Product Specifications for AEG 3482

Molecular Weight

280.33

Formula

C10H8N4O2S2

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

CAS Number

63735-71-7

PubChem ID

698112

InChI Key

MQUYTXDAVCOCMX-UHFFFAOYSA-N

SMILES

NS(=O)(=O)C1=NN2C=C(N=C2S1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.03 100
Ethanol 1.4 5

Preparing Stock Solutions for AEG 3482

The following data is based on the product molecular weight 280.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.57 mL 17.84 mL 35.67 mL
5 mM 0.71 mL 3.57 mL 7.13 mL
10 mM 0.36 mL 1.78 mL 3.57 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for AEG 3482

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AEG 3482

For research use only

Customer Reviews for AEG 3482 (1)

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  • 42 perturbagens used the zebrafish DASPEI screen
    Name: Anonymous
    Species: Zebrafish
    Assay Type: In Vivo
    Cell Line/Tissue: larvae
    Verified Customer | Posted 12/17/2019
    Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound
    AEG 3482 2651

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