AF 64394

Key Product Details

Product Description

AF 64394 is a potent and selective GPR3 inverse agonist (pIC₅₀ = 7.3). Selective for GPR3 over GPR6 and GPR12 (pIC₅₀ values are 5.1 and 4.9, respectively).

Product Specifications for AF 64394

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AF 64394

The following data is based on the product molecular weight 393.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.69 mL	25.39 mL
5 mM	0.51 mL	2.54 mL	5.08 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Godlewski Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue. Sci.Rep. 2015 PMID: 26455425
• Jensen The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg.Med.Chem.Lett. 2014 PMID: 25442311

Product Documents for AF 64394