AG 045572

Key Product Details

Product Description

AG 045572 is a selective gonadotropin-releasing hormone (GnRH) receptor antagonist (K_i values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Suppresses testosterone and luteinising hormone (LH) levels in vivo.

Product Specifications for AG 045572

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AG 045572

The following data is based on the product molecular weight 491.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.17 mL	20.34 mL
5 mM	0.41 mL	2.03 mL	4.07 mL
10 mM	0.20 mL	1.02 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Anderes Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats. J.Pharmacol.Exp.Ther. 2003 PMID: 12606616
• Iatsimirskaia Effect of testost. suppression on the pharmacokinetics of a potent GnRH receptor antagonist. Pharm.Res. 2002 PMID: 11883648

Product Documents for AG 045572