Chemical Name: 3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide
Biological ActivityAG 825 is a selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Tyrphostins. 3. Structure-activity relationship studies of α-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Gazit et al.
Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrphostins.
Osherov et al.
Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-21.
Murillo et al.
Cancer Res., 2001;61:7408
Citations for AG 825
The citations listed below are publications that use Tocris products. Selected citations for AG 825 include:
5 Citations: Showing 1 - 5
Neuregulin1-β decreases interleukin-1β-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability.
Authors: Wu Et al.
J Neurochem 2016;136:250
Neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering HER2/HER3 activation.
Authors: Lee Et al.
Cancer Res 2014;74:341
Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.
Authors: Akhtar Et al.
PLoS One 2013;8:e67813
The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer.
Authors: Lucchetti Et al.
PLoS One 2013;8:e55355
ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation.
Authors: Kedrin Et al.
Clin Cancer Res 2009;15:3733
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