AG 879
Chemical Name: (2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide
Purity: ≥99%
Biological Activity
AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Decreases cellular proliferation in human muscular sarcoma cell lines. Also inhibits ErbB2 and VEGFR-2 (IC50 values are approximately 1 μM for both).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Nerve Growth Factor Secretion From Pulp Fibroblasts is Modulated by Complement C5a Receptor and Implied in Neurite Outgrowth
Sci Rep, 2016;6(0):31799. -
The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation.
He et al.
Cancer Biol.Ther., 2004;3:96 -
Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study.
Rende et al.
Anticancer Drugs, 2006;17:929
Product Datasheets
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Citation for AG 879
The citations listed below are publications that use Tocris products. Selected citations for AG 879 include:
1 Citation: Showing 1 - 1
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Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
Authors: Ledonne Et al.
Mol Psychiatry 2015;20:959
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